Generic Lamictal Tablets (Lametec) – Product Information
Generic Lamictal (Lametec tablets, manufactured by Cipla Ltd.) is an anticonvulsant medication used in the treatment of epilepsy and bipolar disorder. It works by decreasing abnormal electrical activity in the brain.For epilepsy, Lametec Tablets (Generic Lamictal) is used in partial or generalised seizures including Lennox-Gastaut Syndrome. It is also used off-label as an adjunct in treating clinical depression.
The active ingredient present in Generic Lamictal tablets is Lamotrigine.
Lamotrigine is marketed under trade names such as Lamictal ®, Lamictal® CD, Lamictal® ODT, Lamictal® XR and Lametec DT .
Dosage And Administration
Lametec DT (Generic Lamictal) comes as an oral tablet in 25 mg, 50 mg and 100 mg dosage forms. The recommended adult Oral dosage of Generic Lamictal is given below:
Dosage for Treatment of Epilepsy Add-On Therapy In Adults (over 12 years of age)
In patients taking valproate with/without any other anti-epileptic drug (AED), the initial Generic Lamotrigine Tablets (Lametec) dose is 25 mg every alternate day for two weeks, followed by 25 mg once a day for two weeks. Thereafter, the dose should be increased by a maximum of 25-50 mg every 1-2 weeks until the optimal response is achieved. The usual maintenance dose to achieve optimal response is 100-200 mg/day given once a day or in two divided doses.
In those patients taking enzyme inducing AEDs or other medications that induce lamotrigine glucuronidation with/without other AEDs (except valproate), the initial Generic Lamotrigine Tablets (Lametec) dose is 50 mg once a day for two weeks, followed by 100 mg/day given in two divided doses for two weeks.
Thereafter, the dose should be increased by a maximum of 100 mg every 1-2 weeks until the optimal response is achieved. The usual maintenance dose to achieve optimal response is 200- 400 mg/day given in two divided doses. Some patients have required 700 mg/day of lamotrigine to achieve the desired response.
Dosage for Bipolar Disorder Adults (18 years of age and over):
Because of the risk of rash, the initial dose and subsequent dose escalation should not be exceeded. Lamotrigine is recommended for use in bipolar patients at risk for a future depressive episode. The recommended initial adult dosage of Lametec DT is 25 mg once daily for 2 weeks, followed by 50 mg once daily for 2 weeks.
For Patients NOT TAKING Carbamazepine, Phenytoin, Phenobarbital, Primidone, or Valproate
Weeks 1 and 2 25 mg daily
Weeks 3 and 4 50 mg daily
Week 5 100 mg daily
Week 6 and 7 200 mg daily
Generic Lamictal Tablets (Lametec) - Contraindications
Generic Lamictal is contraindicated for patients with hypersensitivity to or Lamotrigine any of the inactive ingredients present in Generic Lamictal (Lametec DT)
Generic Lamictal Tablets (Lametec) - Warnings and Precautions
The following precautions have to be taken when undergoing treatment with Generic Lamictal tablets:
- Life threatening serious rash and/or rash-related death may result
- Fatal or life-threatening hypersensitivity reaction: Multiorgan hypersensitivity reactions, also known as drug reaction with eosinophilia and systemic symptoms, may be fatal or life threatening. Early signs may include rash, fever, and lymphadenopathy. These reactions may be associated with other organ involvement, such as hepatitis, hepatic failure, blood dyscrasias, or acute multiorgan failure. Generic Lamictal Tablets should be discontinued if alternate cause for this reaction is not found.
- Blood dyscrasias (e.g., neutropenia, thrombocytopenia, pancytopenia May occur, either with or without an associated hypersensitivity syndrome.
- Suicidal behavior and ideation.
- Clinical worsening, emergence of new symptoms, and suicidal ideation/behaviors may be associated with treatment of bipolar disorder. Patients should be closely monitored, particularly early in treatment or during dosage changes.
- Aseptic meningitis reported in pediatric and adult patients.
- Medication errors involving Generic Lamictal (Lametec DT) have occurred. In particular the names Generic Lamictal or lamotrigine can be confused with names of other commonly used medications. Medication errors may also occur between the different formulations of Lametec.
Side Effects of Generic Lamotrigine Tablets (Lametec)
The common adverse effects (incidence 10% or greater) reported in patients treated with Lamotrigine (Lametec DT Tablets) in adult epilepsy clinical studies were dizziness, headache, diplopia, ataxia, nausea, blurred vision, somnolence, rhinitis, and rash.
Additional adverse reactions (incidence 10% or greater) reported in children in epilepsy clinical studies included vomiting, infection, fever, accidental injury, pharyngitis, abdominal pain, and tremor. Most common adverse effects with an incidence rate 5% or more in adult bipolar clinical studies were nausea, insomnia, somnolence, back pain, fatigue, rash, rhinitis, abdominal pain, and xerostomia.
More Details on Generic Lamotrigine Tablets (Lametec)
For more details on Lamotrigine Tablets (Lametec) please read the Prescription Information or watch the presentation below.
