What are Autoimmune Diseases?
Autoimmune diseases arise from an inappropriate immune response of the body against substances and tissues normally present in the body. Your body's immune system protects you from disease and infection. But in case of patients with an autoimmune disease, the immune system can't tell the difference between healthy body tissue and antigens and consequently the immune system attacks healthy cells in the body.
The treatment of autoimmune diseases is typically with immunosuppression-medication that decreases the immune response.
Generic Rheumatrex (Neotrexate Tablets) – Product Information
Generic Rheumatrex (Neotrexate Tablets), an antimetabolite and antifolate drug. is used in treatment of cancer, neoplastic diseases, severe psoriasis (a skin disease which is characterised by red, scaly patches on some areas of the body), autoimmune diseases, ectopic pregnancy, Eczema, Lymphoma, Trophoblastic Disease and adult rheumatoid arthritis (Disease in which the body attacks its own joints).
The active ingredient present in Generic Rheumatrex is Methotrexate.
Methotrexate is available as Neotrexate, Rheumatrex, Trexall, MTX, Amethopterin and generic Methotrexate.
Neotrexate Tablets (Generic Rheumatrex) are manufactued by GlaxoSmithKline India
Generic Rheumatrex (Neotrexate Tablets) - Contraindications
Generic Rheumatrex (Neotrexate Tablets) is contraindicated in patients with a known hypersensitivity to Methotrexate or to any component of this medication. It is also contraindicated in pregnant women and nursing mothers.
Methotrexate (Neotrexate Tablets) is also contraindicated in patients with alcoholism, alcoholic liver disease or other chronic liver disease
those who have overt or laboratory evidence of immunodeficiency syndromes as well as those who have preexisting blood dyscrasias, such as bone marrow hypoplasia, leukopenia, thrombocytopenia or significant anemia.
Generic Rheumatrex (Neotrexate Tablets) - Dosage
The dosage of Generic Rheumatrex (Neotrexate Tablets) is different for different diseases and treatments. The adult dosage for some indications is given below:
Choriocarcinoma and similar trophoblastic diseases:
Methotrexate is administered orally in doses of 15 to 30 mg daily for a five-day course. Such courses are usually repeated for 3 to 5 times as required, with rest periods of one or more weeks interposed between courses, until any manifesting toxic symptoms subside.
Adult Rheumatoid Arthritis:
Recommended Starting Dosage Schedules
1. Single oral doses of 7.5 mg once weekly.
2. Divided oral dosages of 2.5 mg at 12 hour intervals for 3 doses given as a course once weekly
Polyarticular-Course Juvenile Rheumatoid Arthritis:
The recommended starting dose is 10 mg/m2 given once weekly
Side Effects of Generic Rheumatrex Tablets (Methotrexate)
The most common side effects of Generic Rheumatrex Tablets (Methotrexate) include ulcerative stomatitis, leukopenia, nausea, and abdominal distress. Other commonly reported side effects are malaise, undue fatigue, chills and fever, dizziness and decreased resistance to infection.
Generic Rheumatrex (Neotrexate Tablets) - More Details
For more details please read the Prescription Information or watch the presentation below:
