Prevention of Endometrial Hyperplasia using Generic Prometrium capsules

Generic Prometrium capsules (Micronized Progesterone) – Product Information

Generic Prometrium capsules (Micronized Progesterone) are indicated for use in the prevention of endometrial hyperplasia in nonhysterectomized postmenopausal women who are receiving conjugated estrogens tablets. They are also indicated for use in secondary amenorrhea as well as for maintaining pregnancy.
The active ingredient present in Generic Prometrium Capsules is Micronized Progesterone.
Micronized Progesterone is marketed under trade names such as Prometrium capsules, Utrogestan capsules and Endogest Soft Gelatin capsules. Endogest is available in strengths of 100 mg and 200 mg.

Dosage And Administration

Generic Prometrium (Endogest Soft Gelatin capsules) comes as an oral capsule in 100 mg and 200 mg dosage forms . The recommended adult Oral dosage of Micronized Progesterone Soft Gelatin capsules (Generic Prometrium) for adults is given below:
Prevention of Endometrial Hyperplasia:
Micronized Progesterone capsules should be given as a single daily dose in the evening, 200 mg orally for 12 days sequentially per 28 day cycle, to postmenopausal women with a uterus who are receiving daily conjugated estrogens tablets.
Secondary Amenorrhea:
Micronized Progesterone Capsules may be given as a single daily dose of 400 mg in the evening for 10 days.

Generic Prometrium (Endogest Soft Gelatin capsules) - Contraindications

Generic Prometrium (Endogest Soft Gelatin capsules) is contraindicated in patients that have hypersensitivity to Micronized Progesterone, soya, peanut or to any ingredient in the formulation of the capsule. It is also containdicated in patients with the following conditions:

• active hepatic dysfunction or disease, especially of the obstructive type;
• personal history of known or suspected estrogen dependent or progestin dependent malignant neoplasia (e.g. breast cancer or endometrial cancer)
• endometrial hyperplasia;
• undiagnosed abnormal genital bleeding;
• known or suspected pregnancy;
• active or past history of arterial thromboembolic disease (e.g. stroke, myocardial infarction, coronary heart disease)
• classical migraine;
• active or past history of confirmed venous thromboembolism (such as deep venous thrombosis or pulmonary embolism) or active thrombophlebitis;
• partial or complete loss of vision due to ophthalmic vascular disease

Side Effects of Generic Prometrium (Endogest Soft Gelatin capsules)

The common possible side effects reported in patients treated with Generic Prometrium (Endogest Soft Gelatin capsules) include Headache, Breast Tenderness, Joint Pain, Depression, Dizziness, Abdominal Bloating, Hot Flashes, Urinary Problems, Abdominal Pain, Vaginal Discharge, Nausea / Vomiting, Worry, Chest Pain, Diarrhea, Night Sweats, Breast Pain, Swelling of Hands and Feet, Vaginal Dryness, Constipation, Breast Carcinoma, Breast Excisional Biopsy and Cholecystectomy.

More Details on Generic Prometrium Capsules

For more details on Generic Prometrium (Endogest Soft Gelatin capsules) please read the prescription information or watch the presentation below.

Treatment of Hypertension & Oedematous Disorders with Aldactone Tablets

Aldactone Tablets (Spironolactone) – Product Information

Aldactone Tablets manufactured by RPG Life Science Ltd. are used to treat essential hypertension (high blood pressure with an unknown cause), oedematous disorders(swelling with fluid), including congestive cardiac failure, diagnosis and treatment of primary aldosteronism, reducing or preventing potassium loss due to thiazide diuretics, add-on therapy in malignant hypertension, prevention of low amounts of potassium in the blood in patients taking digitalis, treatment of hirsutism, treatment of patients with hypokalemia when other measures are considered inappropriate or inadequate and other conditions. Aldactone is available as tablets of 25 mg and 100 mg . Aldactone oral tablets contain 25 mg or 100 mg of the active ingredient spironolactone respectively.
Aldactone acts by working against the effects of a hormone called aldosterone. Too much aldosterone causes increased amounts of sodium (a mineral) and water to be retained by the kidneys, while too much potassium is removed from the body.
Aldactone also has a moderate ability to act against male sex hormones (anti-androgenic effect). Because of this, Aldactone is effective in the treatment of female hirsutism (excess body hair). It reduces hair growth, thickness and hair colour.

Aldactone Tablets - Contraindications

Aldactone is contraindicated in patients that have hypersensitivity to Spironolactone or any inactive component of this medicine. Aldactone Tablets are also contraindicated for patients with anuria, acute renal insufficiency, significant impairment of renal excretory function, Addison's disease or hyperkalemia, pregnancy or with concomitant use of eplerenone.

Aldactone Tablets - Dosage

The recommended dosage of Aldactone Tablets for various indications is given below:
Establishing the diagnosis of Primary Hyperaldosteronism:
Long test: ALDACTONE is administered at a daily dosage of 400 mg for three to four weeks.
Short test: ALDACTONE is administered at a daily dosage of 400 mg for four days.
Edema in adults (congestive heart failure, hepatic cirrhosis, or nephrotic syndrome):
An initial daily dosage of 100 mg of Aldactone administered in either single or divided doses is recommended, but may range from 25 to 200 mg daily. When given as the sole agent for diuresis, Aldactone should be continued for at least five days at the initial dosage level, after which it may be adjusted to the optimal therapeutic or maintenance level.
Essential hypertension:
For adults, an initial daily dosage of 50 to 100 mg of Aldactone administered in either single or divided doses is recommended.
Hypokalemia:
Aldactone in a dosage ranging from 25 mg to 100 mg daily is useful in treating a diuretic-induced hypokalemia, when oral potassium supplements or other potassium-sparing regimens are considered inappropriate.
Severe Heart Failure (NYHA class III – IV):
Treatment should be started with Aldactone 25 mg once daily if the patient’s serum potassium is equal to 5.0 mEq/L and the patient’s serum creatinine is equal to 2.5 mg/dL. Patients who tolerate 25 mg once daily may have their dosage increased to 50 mg once daily as clinically indicated. Patients who do not tolerate 25 mg once daily may have their dosage reduced to 25 mg every other day.

Side Effects of Aldactone Tablets

The side effects of Aldactone Tablets include:
Digestive: Gastric bleeding, ulceration, gastritis, diarrhea and cramping, nausea, vomiting.
Endocrine: Gynecomastia (see Precautions), inability to achieve or maintain erection, irregular menses or amenorrhea, postmenopausal bleeding. Carcinoma of the breast has been reported in patients taking Aldactone but a cause and effect relationship has not been established.
Hematologic: Agranulocytosis.
Hypersensitivity: Fever, urticaria, maculopapular or erythematous cutaneous eruptions, anaphylactic reactions, vasculitis.
Metabolism: Hyperkalemia.
Nervous system /psychiatric: Mental confusion, ataxia, headache, drowsiness, lethargy.
Liver / biliary: A very few cases of mixed cholestatic/hepatocellular toxicity, with one reported fatality, have been reported with Aldactone administration.
Renal: Renal dysfunction (including renal failure).

Aldactone Tablets - More Details

For more details please read the prescription information or watch the presentation below:

Treatment of Depression Using Generic Effexor XR Capsules

What is Depression?

Everyone occasionally feels sad, blue,unhappy, miserable, or down in the dumps. These feelings are usually short-lived and pass within a couple of days. When you have Clinical Depression , it interferes with daily life for weeks or longer and causes pain for both you and those who care about you. Depression is a common but serious illness which can get better with treatment. Medications, psychotherapies, and other methods can effectively treat people with depression.
Depressive illnesses are disorders of the brain and are most likely to be caused by a combination of genetic, biological, environmental, and psychological factors.
A person is diagnosed with depression can be treated in several ways. The most common treatments are medication and psychotherapy. Antidepressants primarily work on brain chemicals called neurotransmitters, especially serotonin and norepinephrine. Other antidepressants work on the neurotransmitter dopamine.
The newest and most popular antidepressants are called selective serotonin reuptake inhibitors (SSRIs) which include Fluoxetine (Prozac), sertraline (Zoloft), escitalopram (Lexapro), paroxetine (Paxil), and citalopram (Celexa) are some of the most commonly prescribed SSRIs for depression. Serotonin and norepinephrine reuptake inhibitors (SNRIs) are similar to SSRIs and include venlafaxine (Effexor) and duloxetine (Cymbalta). Most are available in generic versions such as Venlor XR Capsules manufactured by Cipla Ltd., India is a generic version of Effexor XR (Venlafaxine)

Generic Effexor XR (Venlor XR Capsules) – Product Information

Generic Effexor XR is used in the treatment and prevention of relapse of depression. Effexor XR (venlafaxine hydrochloride) extended-release capsules is indicated for the treatment of major depressive disorder, Generalized Anxiety Disorder (GAD), Social Anxiety Disorder, also known as Social Phobia as well as for the treatment of panic disorder. It is also used for the prevention of relapses of the initial episode of depression or for the prevention of the recurrence of new depressive episodes. The active ingredient present in Generic Effexor XR is Venlafaxine Hydrochloride. Venlor XR is manufactured by Cipla Ltd. in strengths of 37.5 mg, 75 mg and 150 mg. The capsules contain venlafaxine hydrochloride equivalent to 37.5 mg, 75 mg, or 150 mg venlafaxine respectively.

Generic Effexor XR - Contraindications

Generic Effexor XR is contraindicated in patients that have hypersensitivity to Venlafaxine Hydrochloride or any inactive component of this medicine. Concomitant use with MAOIs is also contraindicated. Generic Effexor XR is also contraindicated in patients aged below 18 years, patients with very high risk of a serious cardiac ventricular arrhythmia, uncontrolled hypertension.

Generic Effexor XR (Venlor XR Capsules) - Dosage

Generic Effexor XR should be administered in a single dose with food either in the morning or in the evening at approximately the same time each day. Each capsule should be swallowed whole with fluid and not divided, crushed, chewed, or placed in water. The dosage varies as per the indication being treated.The recommended dosage of Venlor XR Capsules for various indications is given below:
Major Depressive Disorder:
For most patients, the recommended starting dose for Effexor XR is 75 mg/day, administered in a single dose.
Generalized Anxiety Disorder:
For most patients, the recommended starting dose for Effexor XR is 75 mg/day, administered in a single dose.
Social Anxiety Disorder (Social Phobia):
The recommended dose of Generic Effexor XR (Venlafaxine Hydrochloride) is 75 mg/day, administered in a single dose.
Panic Disorder:
The recommended initial dose of Generic Effexor XR is a single dose of 37.5 mg/day for 7 days.

Side Effects of Generic Effexor XR

The adverse events most commonly associated with Venlor XR (Generic Effexor XR Capsules)administration are nervous system complaints, such as headache, dizziness, insomnia, somnolence, nervousness and dry mouth; gastrointestinal complaints, including anorexia, nausea and constipation; and abnormal ejaculation/orgasm, sweating and asthenia. Many of the frequently observed adverse events are dose related. With continued theatment, these adverse effects generally decrease in frequency and intensity, and usually do not require discontinuation.

Generic Effexor XR - More Details

For more details please read the prescription information or watch the presentation below:

Generic Arimidex Tablets for Treatment of Breast Cancer in Post-menopausal Women

Generic Arimidex Tablets – Product Information

Generic Arimidex (Anastrozole tablets) is used for the treatment of early breast cancer in hormone receptor positive post-menopausal women. It is also used for the Adjuvant treatment of early breast cancer in hormone receptor positive postmenopausal women who have received 2 to 3 years of adjuvant Tamoxifen. It is also used for reduction in the incidence of contralateral breast cancers in post menopausal women receiving as adjuvant treatment for early breast cancer and treatment of advanced breast cancer in post-menopausal women.
The active ingredient present in Generic Arimidex Tablets is Anastrozole.
Generic Anastrozole is marketed under trade names such as Arimidex, Armotraz, Redest and Anazole.
Anastrozole prevents the production of certain types of hormones in the body. It is used to treat breast cancer in women who have already gone through the menopause. Arimidex is only used to treat breast cancers which are sensitive to hormones. It is not suitable for children or for treating cancers which are not hormone sensitive.

Dosage And Administration

Generic Arimidex (Anastrozole tablets) comes as an oral tablet in 1 mg dosage forms . The recommended dosage of Generic Arimidex for adults is one tablet (1 mg) of Anastrozole tablets (Anazole) to be taken orally once a day. Anastrozole can be taken with or without food.

Side Effects of Generic Arimidex Tablets

The common possible side effects of Generic Arimidex (Anastrozole tablets) occuring in 1% or more of the patients are Hot flushes, Gastrointestinal upsets including nausea and diarrhoea, Headache, Rash, Loss of hair, Vaginal dryness, Asthenia, joint pain or stiffness, Carpal Tunnel Syndrome, Increases in alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase.

Anastrozole Tablets (Generic Arimidex) - More Details

For more details on Anastrozole Tablets (Anazole) please read Prescribing Information or watch the presentation below:

Anastrozole Tablets for Treatment of Breast Cancer in Post-menopausal Women

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