Treatment of Chronic Musculoskeletal Pain, Diabetic Peripheral Neuropathic Pain , Fibromyalgia and Major Depressive Disorder

Generic Cymbalta Capsules – Product Information

Generic Cymbalta Capsules belongs to a category of medications called Serotonin and Norepinephrine Reuptake Inhibitor (SNRI) which work to increase the amounts of serotonin and norepinephrine, naturally occuring chemicals in the brain that help maintain mental balance and stop the movement of pain signals in the brain.
Generic Cymbalta Capsules are used to treat Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD), Diabetic Peripheral Neuropathic Pain (DPNP), Fibromyalgia (FM) and Chronic Musculoskeletal Pain. It is available as Dulot capsules ( Lupin Ltd. ), Duzela capsules (Sun Pharma) and Duvanta tablets (Intas Pharmaceuticals Ltd). The active ingredient pharmaceutical present in Generic Cymbalta is Duloxetine.
Duloxetine is also marketed under brand names such as Ariclaim, Xeristar, Yentreve, Duzela, Dulane, Cymbalta, and Cymgen (in South Africa).

Generic Cymbalta Capsules - Contraindications

Use of Generic Cymbalta is contraindicated to treat patients with the following conditions:

• Generic Cymbalta Capsules are contraindicated in patients with ahypersensitivity to Duloxetine or any inactive ingredient present in generic Cymbalta capsules.
• Generic Cymbalta is contraindicated in patients with hepatic impairment.
• Generic Cymbalta should not be used in combination with potent CYP1A2 inhibitors
• The use of Monoamine Oxidase Inhibitors (MAOIs) to treat psychiatric disorders with Generic Cymbalta or within five days of stopping treatment with Generic Cymbalta is contraindicated because of an increased risk of serotonin syndrome. Additionally the use of Generic Cymbalta within 14 days of stopping an MAOI intended to treat psychiatric disorders is also contraindicated.
• Starting treatment with Generic Cymbalta in a patient who is being treated with MAOIs such as linezolid or intravenous methylene blue is also contraindicated because of an increased risk of serotonin syndrome.

Generic Cymbalta - Dosage

Generic Cymbalta (Duloxetine) comes as oral Capsules in 20 mg, 30 mg, 40 mg and 60 mg dosage forms. Take Generic Cymbalta once daily, with or without food. Generic Cymbalta capsules have to be swallowed whole. You must not crush or chew and the capsule should not be opened. The recommended adult Oral dosage of Generic Cymbalta is given below:
Dosage for Treatment of Major Depressive Disorder (MDD):
Starting Dose: 40mg/day to 60mg/day
Target Dose Acute Treatment: 40 mg/day (20 mg twice daily) to 60 mg/day (once daily or as 30 mg twice daily);
Target Dose Maintenance Treatment: 60 mg/day
Dosage for Treatment of Diabetic Peripheral Neuropathic Pain (DPNP):
Starting Dose: 60mg/day
Target Dose: 60 mg/day (once daily)
Dosage for Treatment of Generalized Anxiety Disorder (GAD):
Starting Dose:60mg/day
Target Dose: 60 mg/day (once daily)
Dosage for Treatment of Fibromyalgia (FM):
Starting Dose:30mg/day
Target Dose: 60 mg/day (once daily)
Dosage for Treatment of Chronic Musculoskeletal Pain:
Starting Dose: 30mg/day
Target Dose: 60 mg/day (once daily)

Side Effects of Generic Cymbalta

The most common side effects reported in patients treated with Generic Cymbalta include nausea, vomiting, constipation, diarrhea, heartburn, stomach pain, decreased appetite, dry mouth, increased urination, difficulty urinating, sweating or night sweats, dizziness, headache, tiredness, weakness, drowsiness, muscle pain or cramps, changes in sexual desire or ability, uncontrollable shaking of a part of the body. Please inform your doctor if any of the above symptoms are severe or do not go away.
In case you experience any of the following serious side effects listed below, call your doctor immediately or get emergency medical treatment:

• unusual bruising or bleeding
• pain in the upper right part of the stomach
• swelling of the abdomen
• itching
• yellowing of the skin or eyes
• dark colored urine
• loss of appetite
• extreme tiredness or weakness
• confusion
• flu-like symptoms
• fever, sweating, confusion, fast or irregular heartbeat, and severe muscle stiffness
• fever
• blisters or peeling skin
• rash
• hives
• difficulty breathing or swallowing
• swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
• hoarseness

Generic Cymbalta - More Details

For more details on Generic please read the Prescription Information or watch the presentation below:

Generic Cymbalta Capsules for Treatment of Major Depressive Disorder

Ginette-35 for Contraception and Treatment of Severe Acne and Hirsutism

Ginette-35 Tablets – Product Information

Ginette-35 Birth Control Pill is used for the treatment of women with severe acne, accompanied by excess oily secretions of the skin, inflammation or formation of nodes, and excess hair on the face, chest, abdomen or legs. Ginette-35 will also provide effective oral contraception in this patient group.
Treatment with Ginette-35 for 3 to 4 months leads to the healing of existing acne efflorescences. The excessive greasiness of the hair and skin generally disappears earlier. The loss of hair which frequently accompanies seborrhoea likewise diminishes. In women experiencing mild forms of hirsutism and in particular, slightly increased facial hair, results do not, however become apparent until after several months of use.
You should not take Ginette-35 for the purpose of birth control alone, however, during treatment with Ginette-35, ovulation will not take place if the medication is taken as prescribed.
The active pharmaceutical ingredients in Ginette-35 pills are 2mg cyproterone acetate and 0.035mg ethinyl estradiol. Ginette-35 is manufactured by Cipla Ltd, a leading generics company in India.

Dosage And Administration

One tablet of Ginette-35 Birth Control Pill is to be taken daily. The tablets must be taken at about the same time every day, with some liquid as needed. Tablet taking should be continuous. One tablet of Ginette-35 is to be taken daily for 21 consecutive days. Withdrawal bleeding should usually occur on day 2 to 3 after the last tablet is taken. Each subsequent pack is started after a 7 day tablet free interval.
How to start Ginette-35 Tablets:
Tablet taking has to start on day 1 of the woman's natural cycle (i.e. the first day of her menstrual bleeding). Starting on day 2 -5 of the menstrual cycle is permitted, but during the first cycle a barrier method is recommended in addition for the first 7 days of tablet-taking. When you have taken all 21 tablets in this pack, wait 7 days and then start a new pack of Ginette-35. During the 7 days that you are not taking any tablets, you should have your period, usually 2-4 days after you have taken your last tablet.
The first tablet in every subsequent pack will always be taken on the same day of the week that you first began taking Ginette-35 tablets regardless of whether your bleeding has already ceased (which it usually has) or is still continuing.

Ginette-35 Tablets - Missed Dose Instructions

The management of missed tablets can be guided by the following two basic rules: Tablet-taking must never be discontinued for more than 7 days; and 7 days of uninterrupted tablet-taking are required to attain adequate suppression of the hypothalamic-pituitary-ovarian axis.
If the user is less than 12 hours late in taking a tablet, contraceptive protection is not reduced. The woman should take the tablet as soon as she remembers and should take further tablets at the usual time.
Week 1: The user should take the last missed tablet as soon as she remembers, even if this means taking 2 tabs at the same time. She then continues to take tablets at her usual time. In addition, a barrier method eg, a condom, should be used for the next 7 days.
Week 2: The user should take the last missed tablet as soon as she remembers, even if this means taking 2 tabs at the same time. She then continues to take tablets at her usual time. Provided that the woman has taken her tablets correctly in the 7 days preceding the 1st missed tablet, there is no need to use extra contraceptive precautions. However, if this is not the case or if she missed more than one tablet, the woman should be advised to use extra precautions for 7 days.
Week 3: The risk of reduced reliability is imminent because of the forthcoming tablet-free interval. However, by adjusting the tablet-intake schedule, reduced contraceptive protection can still be prevented. By adhering to either of the following 2 options, there is therefore no need to use extra contraceptive precautions, provided that in the 7 days preceding the first missed tablet, the woman has taken all tablets correctly. If this is not the case, the woman should be advised to follow the first of these 2 options and to use extra precautions for the next 7 days as well.
The user should take the last missed tablet as soon as she remembers, even if this means taking 2 tablets at the same time. She then continues to take tablets at her usual time. The next pack must be started as soon as the current pack is finished i.e., no gap should be left between packs. The user is unlikely to have a withdrawal bleed until the end of the second pack, but she may experience spotting or breakthrough bleeding on tablet-taking days.

Ginette-35 Tablets - Contraindications

Ginette-35 is contraindicated in patients with

• Hypersensitivity to the active ingredients cyproterone acetate and/or ethinyl estradiol or to any of the other components of the medicine.
• Personal or family history of confirmed, idiopathic venous thromboembolism (VTE)(where a family history refers to VTE in a sibling or parent at a relatively early age).
• Presence or a history of venous or arterial thrombotic/thromboembolic events (e.g. deep venous thrombosis, pulmonary embolism, myocardial infarction) or of a cerebrovascular accident.
• Sickle-cell anaemia
• Presence or history of prodromi of a thrombosis (e.g. transient ischaemic attack, angina pectoris).
• Presence of severe or multiple risk factor(s) for venous or arterial thrombosis
• History of migraine with focal neurological symptoms.
• Diabetes mellitus with vascular involvement.
• Pancreatitis or a history thereof if associated with severe hypertriglyceridemia.Severe hepatic disease as long as liver function values have not returned to normal.Jaundice or persistent itching during a previous pregnancy, Dubin-Johnson syndrome, Rotor syndrome
• History of deterioration of otosclerosis during pregnanacy.
• Presence or history of liver tumors (benign or malignant).
• Known or suspected sex steroid influenced malignancies (e.g. of the genital organs or the breasts).
• Undiagnosed vaginal bleeding.
• Known or suspected pregnancy.
• Lactation.
• Disorders of lipid metabolism
• History of herpes gestationis

Side Effects of Ginette-35 Tablets

The most common side effects (1% or more) reported in patients treated with Ginette-35 Tablets are nausea, abdominal pain, weight increased, headache,depressed mood, mood altered, breast pain, breast tenderness. The uncommon side effects (Occuring in 1 per thousand or more and less than 1 in 100) are vomiting, diarrhea, fluid retention, migrane, libido decreased, breast hypertrophy, Rash, and urticaria. The rare side effects include contact lens intolerance, hypersensitivity, weight decreased, libido increased, vaginal discharge, breast discharge, Erythema nodosum and erythema multiforme.

Ginette-35 - More Details

For more details please read the Prescription Information or watch the presentation below:

Ginette-35 Contraceptive Tablets

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Novelon Birth Control Pills

Novelon Contraceptive Pills – Product Information

Novelon manufactured by Organon® is a combined oral contraceptive pill. It is a 21-day pill – you take one each day for 21 days, followed by 7 days when you take no pills.
The active ingredients present in Novelon Contraceptive Pills are Desogestrel 0.15 mg and Ethinyl Estradiol 0.03 mg.

Uses Of Novelon Contraceptive Tablets

Novelon Tablets are used for prevention of of pregnancy . To prevent pregnancy it is important to take Novelon as instructed and to start each pack on time.
The following non-contraceptive health benefits have been associated with Novelon Contraceptive pills:
Novelon is also used to treat mild to moderate acne.
Your periods may be lighter and shorter. As a result, the risk of anaemia may be lower. Your period pains may become less severe or may completely disappear.
In addition, some serious disorders have been reported to occur less frequently in users of Combined Pills containing Ethinyl oestradiol. These are: benign breast disease, ovarian cysts, pelvic infections (pelvic inflammatory disease), ectopic pregnancy (pregnancy in which the embryo implants outside of the womb) and cancer of the endometrium (lining of the womb) and ovaries.

Novelon Contraceptive Tablets - Contraindications

Novelon Contraceptive Tablets is contraindicated in patients with the following conditions:

• Hypersensitivity to Desogestrel, Ethinyl Estradiol or any inactive ingredient present in Novelon tablets.
• A disorder affecting the blood circulation: in particular, those conditions relating to thrombosis
• A stroke (caused by a blood clot in or a rupture of a blood vessel in the brain)
• A condition that may be a first sign of a heart attack
• A major surgery
• A history of migraine accompanied by e.g. visual symptoms, speech disability, or weakness or numbness in any part of your body.
• Diabetes mellitus with blood vessel damage.
• Pancreatitis (an inflammation of the pancreas) associated with high levels of fatty substances in your blood.
• Jaundice (yellowing of the skin) or severe liver disease and your liver is not working normally
• A cancer that may grow under the influence of sex hormones (e.g. of the breast or the genital organs).
• A benign or malignant liver tumour.
• Any unexplained vaginal bleeding.
• A disturbance of blood clotting

Novelon - Dosage

Inorder to prevent pregnancy, it is recommended to take Novelon every day for 21 days. Novelon comes in strips of 21 pills, each marked with a day of the week. Take your tablet at the same time every day. Start by taking a pill marked with the correct day of the week. Follow the direction of the arrows on the strip. Take one tablet each day, until you have finished all the 21 pills.
After you have taken all 21 tablets present in the strip, you have seven days when you take no tablets. Swallow each pill whole, with water if necessary. Do not chew the pill. Always check with your doctor or health care advisor if you are not sure.

Side Effects of Novelon Birth Control Pills

Serious possible side effects of Novelon birth control pills include painful swelling in your leg, sudden chest pain, difficulty breathing, heart attack or stroke, severe allergic reaction, breast cancer, cancer of the cervix, severe liver problems.
Other possible side effects of Generic Marvelon include Migraine or headache, Putting on weight or losing weight, Problems with blood sugar, Breast problems, Depression or mood changes Heart or circulation problems, Gynaecological and vaginal problems, Bleeding and spotting between your periods for the first few months, Skin problems, such as rash; brown patches on your face or body (chloasma), Stomach problems, such as nausea; vomiting, Discomfort of the eyes if you wear contact lenses, Gall stones, Chorea and Systemic lupus erythematosus

Novelon Birth Control Pills - More Details

For more details please watch the presentation below:

Prevent Pregnancy using Yasmin Contraceptive Pills

What is Yasmin Contraceptive Pill?

Yasmin Contraceptive Pill is a combined oral contraceptive pill. The contraceptive regimen consists of 21 active film coated tablets each containing 3 mg of Drospirenone and 0.03 mg of Ethinyl Estradiol. The inactive ingredients present in Yasmin pills are lactose monohydrate NF, corn starch NF, modified starch NF, povidone 25000 USP, magnesium stearate NF, hydroxylpropylmethyl cellulose USP, macrogol 6000 NF, talc USP, titanium dioxide USP, ferric oxide pigment, yellow NF.
Yasmin is used to prevent pregnancy. Yasmin is also of some benefit in androgen-related acne, skin conditions or greasy hair.
Women taking Yasmin may also experience the following benefits:improvement in symptoms like bloating, swelling or weight gain related to fluid retention, more regular and lighter periods and a decrease in period pain. Some conditions such as pelvic inflammatory disease, ovarian cysts, ectopic pregnancy, fibrocystic breast changes and cancer of the uterus (womb) and ovaries may be less common in women taking the Pill.

How does Yasmin Contraceptive Pill Work?

When taken correctly, Yasmin works in several ways to prevent you from becoming pregnant including:

• inhibiting the egg release by stopping it maturing
• changing the cervical mucus consistency, making it more difficult for the sperm to reach the egg

Dosage And Administration

Yasmin contraceptive pill comes as an oral tablet containing 3 mg of Drospirenone and 0.03 mg of Ethinyl Estradiol. The recommended Oral dosage of Yasmin contraceptive pills is given below:
Yasmin Dosage for Maximum Contraceptive Effectiveness
To achieve maximum contraceptive effectiveness, Yasmin birth control pills (drospirenone and ethinyl estradiol) must be taken exactly as directed at intervals not exceeding 24 hours.
Yasmin oral contraceptive regimen consists of 21 active tablets. The dosage of Yasmin birth control pills is one tablet daily for 21 consecutive days followed by 7 tablet free days per menstrual cycle. A patient should begin to take Yasmin contraceptive pills on the first day of her menstrual period.
Withdrawal bleeding usually occurs within 3 days following the last active tablets.

Missed Pill Instructions - Yasmin Contraceptive Pills

If You Miss 1 Active Pill:
Take the tablet as soon as you remember. Take the next pill at your regular time. This means you may take two pills in one day.
If You Miss 2 Active Pills In A Row In Week 1 Or Week 2 Of Your Pack:
Take two pills on the day you remember and two pills the next day.Then take one pill a day until you finish the pack. You MUST use another birth control method (such as condoms or spermicides) as a back-up for 7 days after restarting your tablets.
If You Miss 2 Active Pills In A Row In The 3rd Week Or 4th Week:
THROW OUT the rest of the pill pack and start a new pack that same day. You MUST use another birth control method (such as condoms or spermicides) as a back-up for 7 days after restarting your tablets.

Side Effects of Yasmin Birth Control Pill

The commonly occurring possible side effects reported in patients treated with Yasmin contraceptive pill include nausea, stomach pain, changes in weight, headache, including migraines, mood changes, including depression, Irregular uterine bleeding, breast tenderness or pain.

Yasmin Contraceptive Pill - Contraindications

Yasmin Contraceptive Pill is contraindicated in women who are known to have the following medical conditions:

• Hypersensitivity to Drospirenone and/or Ethinyl oestradiol , the active ingredients in Yasmin or any of the inactive ingredients
• Renal impairment
• Adrenal insufficiency
• A high risk of arterial or venous thrombotic diseases. Examples include women who are known to: Smoke, if over age 35, have deep vein thrombosis or pulmonary embolism, now or in the past, have cerebrovascular disease, have coronary artery disease, have thrombogenic valvular or thrombogenic rhythm diseases of the heart (for example, subacute bacterial endocarditis with valvular disease, or atrial fibrillation)
• Have inherited or acquired hypercoagulopathies
• Have uncontrolled hypertension
• Have diabetes mellitus with vascular disease
• Have headaches with focal neurological symptoms or have migraine headaches with or without aura if over age 35
• Undiagnosed abnormal uterine bleeding
• Breast cancer or other estrogen- or progestin-sensitive cancer, now or in the past
• Liver tumor (benign or malignant) or liver disease
• Pregnancy or suspected pregnancy because there is no reason to use Combine Oral Contraceptives during pregnancy

Yasmin Contraceptive Pill - More Details

For more details on Yasmin Contraceptive Pill manufactured by Bayer Schering Pharma please read the Prescription Information or watch the presentation below:

Yasmin Birth Control Pill